Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.63 |
| ▸ | RAB9A | P51151 | 8/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | TP53 | P04637 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.54 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.54 |
| ▸ | CCR6 | P51684 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16699400 | 0.97 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL15393387 | 0.95 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL16699922 | 0.94 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL15393495 | 0.91 | POLB (0.54) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL16700835 | 0.90 | TP53 (0.61) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL16700892 | 0.89 | TP53 (0.59) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL16700048 | 0.86 | RORC (0.55) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL16700902 | 0.86 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL13104425 | 0.85 | SAE1 (0.71) | NPC1RAB9ASMN1; SMN2KMT2ATP53 | |
| SCHEMBL366747 | 0.85 | SMN1; SMN2 (0.74) | NPC1RAB9ASMN1; SMN2KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951033-B2 | Tertiary amines for use in the treatment of cardiac disorders | UNIVERSITETET I OSLO (NO) | 2018-04-24 | — | — | US | disclosed |
| US-20170158657-A1 | TERTIARY AMINES FOR USE IN THE TREATMENT OF CARDIAC DISORDERS | UNIVERSITETET I OSLO (NO) | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158657-A1 | TERTIARY AMINES FOR USE IN THE TREATMENT OF CARDIAC DISORDERS | TNNI3, TNNT2, MYLK2 | NPC1 1181/4885RAB9A 1672/4885SMN1; SMN2 2862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.