Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18939423 | 0.90 | CYP1A2 (0.70) | GAACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18939372 | 0.82 | CYP1A2 (0.81) | GAACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17712437 | 0.77 | GAA (0.61) | GAAMEN1KMT2APOLBLMNA | |
| SCHEMBL583003 | 0.76 | KMT2A (0.83) | GAAMEN1KMT2APOLBLMNA | |
| SCHEMBL19736115 | 0.76 | ADORA2A (0.46) | LMNASMN1; SMN2GPR88ALDH1A1KDM4E | |
| SCHEMBL16254379 | 0.75 | PKM (0.50) | CYP1A2CYP3A4CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL27932526 | 0.74 | POLB (0.69) | GAAMEN1KMT2APOLBLMNA | |
| SCHEMBL13118304 | 0.74 | NPC1 (0.60) | GAAKMT2APOLBLMNAKCNK3 | |
| SCHEMBL25382013 | 0.73 | SMN1; SMN2 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL23784199 | 0.73 | GAA (0.70) | GAAMEN1KMT2APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49594-E1 | Apelin receptor (APJ) agonists and uses thereof | RESEARCH TRIANGLE INSTITUTE (US) | 2023-08-01 | — | — | US | disclosed |
| US-11535630-B2 | Apelin receptor (APJ) agonists and uses thereof | RESEARCH TRIANGLE INSTITUTE (US) | 2022-12-27 | — | — | US | disclosed |
| US-10954247-B2 | Apelin receptor (APJ) agonists and uses thereof | RESEARCH TRIANGLE INSTITUTE (NC) | 2021-03-23 | — | — | US | disclosed |
| US-20210070767-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2021-03-11 | — | — | US | disclosed |
| EP-3386976-A1 | IMPROVED APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | Research Triangle Institute, International (US) | 2018-10-17 | — | — | EP | disclosed |
| US-10100059-B2 | Apelin receptor (APJ) agonists and uses thereof | RESEARCH TRIANGLE INSTITUTE (US) | 2018-10-16 | — | — | US | disclosed |
| US-20180265518-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2018-09-20 | — | — | US | disclosed |
| WO-2017100558-A1 | IMPROVED APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 2017-06-15 | — | — | WO | disclosed |
| US-20170166577-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2017-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166577-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | GAA 4490/4885CYP1A2 4586/4885CYP3A4 4807/4885 |
| US-10100059-B2 | Apelin receptor (APJ) agonists and uses thereof | APLNR, AP1G1, APMAP | GAA 4490/4885CYP1A2 4586/4885CYP3A4 4807/4885 |
| US-11535630-B2 | Apelin receptor (APJ) agonists and uses thereof | APLNR, AP1G1, APMAP | GAA 4490/4885CYP1A2 4586/4885CYP3A4 4807/4885 |
| US-20210070767-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | GAA 4490/4885CYP1A2 4586/4885CYP3A4 4807/4885 |
| US-20180265518-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | GAA 4490/4885CYP1A2 4586/4885CYP3A4 4807/4885 |
| US-10954247-B2 | Apelin receptor (APJ) agonists and uses thereof | APLNR, AP1G1, APMAP | GAA 4490/4885CYP1A2 4586/4885CYP3A4 4807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.