Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30854371 | 0.95 | CYP1A2 (0.58) | CYP1A2MAPK1SMN1; SMN2BDKRB1SLC6A1 | |
| SCHEMBL29466212 | 0.87 | L3MBTL1 (0.44) | CYP1A2MAPK1SMN1; SMN2BDKRB1ALDH1A1 | |
| SCHEMBL18939597 | 0.81 | SMN1; SMN2 (0.50) | MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL29568309 | 0.79 | HRH3 (0.36) | HRH3 | |
| SCHEMBL14979846 | 0.78 | HRH3 (0.34) | BDKRB1SLC6A1HRH3PDCD1CD274 | |
| SCHEMBL16227821 | 0.78 | HRH3 (0.39) | CYP1A2MAPK1SMN1; SMN2SLC6A1HRH3 | |
| SCHEMBL19720585 | 0.77 | CYP1A2 (0.53) | CYP1A2MAPK1SMN1; SMN2SLC6A1LMNA | |
| SCHEMBL1006987 | 0.77 | L3MBTL1 (0.56) | CYP1A2MAPK1SMN1; SMN2BDKRB1SLC6A1 | |
| SCHEMBL12635284 | 0.77 | MAPT (0.40) | BDKRB1SLC6A1ALDH1A1MAPTHRH3 | |
| SCHEMBL1856267 | 0.77 | CYP1A2 (0.83) | CYP1A2MAPK1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114507217-A | Heterocyclic apelin receptor (APJ) agonists and uses thereof | 三角研究所 | 2022-05-17 | — | — | CN | claimed |
| US-RE49594-E1 | Apelin receptor (APJ) agonists and uses thereof | RESEARCH TRIANGLE INSTITUTE (US) | 2023-08-01 | — | — | US | disclosed |
| US-11535630-B2 | Apelin receptor (APJ) agonists and uses thereof | RESEARCH TRIANGLE INSTITUTE (US) | 2022-12-27 | — | — | US | disclosed |
| CN-114507217-A | Heterocyclic apelin receptor (APJ) agonists and uses thereof | 三角研究所 | 2022-05-17 | — | — | CN | disclosed |
| CN-109790151-B | Heterocyclic apelin receptor (APJ) agonists and uses thereof | 三角研究所 | 2022-03-29 | — | — | CN | disclosed |
| US-10954247-B2 | Apelin receptor (APJ) agonists and uses thereof | RESEARCH TRIANGLE INSTITUTE (NC) | 2021-03-23 | — | — | US | disclosed |
| US-20210070767-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2021-03-11 | — | — | US | disclosed |
| EP-3386976-A1 | IMPROVED APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | Research Triangle Institute, International (US) | 2018-10-17 | — | — | EP | disclosed |
| US-10100059-B2 | Apelin receptor (APJ) agonists and uses thereof | RESEARCH TRIANGLE INSTITUTE (US) | 2018-10-16 | — | — | US | disclosed |
| US-20180265518-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2018-09-20 | — | — | US | disclosed |
| WO-2017100558-A1 | IMPROVED APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 2017-06-15 | — | — | WO | disclosed |
| US-20170166577-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2017-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166577-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | CYP1A2 4586/4885MAPK1 4029/4885SMN1; SMN2 3043/4885 |
| US-10100059-B2 | Apelin receptor (APJ) agonists and uses thereof | APLNR, AP1G1, APMAP | CYP1A2 4586/4885MAPK1 4029/4885SMN1; SMN2 3043/4885 |
| US-11535630-B2 | Apelin receptor (APJ) agonists and uses thereof | APLNR, AP1G1, APMAP | CYP1A2 4586/4885MAPK1 4029/4885SMN1; SMN2 3043/4885 |
| US-20210070767-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | CYP1A2 4586/4885MAPK1 4029/4885SMN1; SMN2 3043/4885 |
| US-20180265518-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | CYP1A2 4586/4885MAPK1 4029/4885SMN1; SMN2 3043/4885 |
| US-10954247-B2 | Apelin receptor (APJ) agonists and uses thereof | APLNR, AP1G1, APMAP | CYP1A2 4586/4885MAPK1 4029/4885SMN1; SMN2 3043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.