Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 15/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 15/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.59 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | CRHBP | P24387 | 4/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712239 | 0.81 | MEN1 (0.72) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL28197565 | 0.81 | HDAC6 (0.64) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL12660521 | 0.80 | MEN1 (0.64) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL28198225 | 0.79 | HDAC6 (0.71) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL16784368 | 0.79 | MEN1 (0.68) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL22699960 | 0.79 | MEN1 (0.80) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL28203805 | 0.78 | HDAC6 (0.70) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL18648444 | 0.78 | MEN1 (0.64) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL12696859 | 0.77 | HDAC3 (0.80) | MEN1KMT2ALMNAHDAC6HDAC3 | |
| SCHEMBL12660535 | 0.77 | HDAC3 (0.65) | MEN1KMT2ALMNAHDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947839-B2 | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use | GENENTECH, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| EP-1817059-A2 | CONJUGATES OF 1,8-BIS-NAPHTHALIMIDES WITH AN ANTIBODY | Genentech, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2007064345-A9 | HETEROCYCLIC-SUBSTITUTED BIS-1,8 NAPHTHALIMIDE COMPOUNDS, ANTIBODY DRUG CONJUGATES, AND METHODS OF USE | GENENTECH INC (US) | 2007-07-12 | — | — | WO | disclosed |
| US-20070134243-A1 | Antibody drug conjugates and methods | GENENTECH, INC. | 2007-06-14 | — | — | US | disclosed |
| US-20060182751-A1 | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use | GENENTECH, INC. (US) | 2006-08-17 | — | — | US | disclosed |
| WO-2006060533-A2 | CONJUGATES OF 1, 8-BIS-NAPHTHALIMIDES WITH AN ANTIBODY | GENENTECH, INC. (US) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060182751-A1 | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use | CCNY, CCNI, MKI67 | MEN1 1399/4885KMT2A 707/4885LMNA 426/4885 |
| US-20070134243-A1 | Antibody drug conjugates and methods | BOD1L1, MKI67, CCNI | MEN1 1674/4885KMT2A 1301/4885LMNA 774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.