Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 5/20 | 0.36 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18944013 | 0.83 | TDP1 (0.39) | CDK9ULK1BRD4 | |
| SCHEMBL18944019 | 0.82 | ULK1 (0.47) | CDK9CCNT1ULK1BTKBRD4 | |
| SCHEMBL20034121 | 0.80 | CDK9 (0.42) | CDK9CCNT1ULK1 | |
| SCHEMBL18944018 | 0.79 | ULK1 (0.45) | CDK9CCNT1ULK1BRD4 | |
| SCHEMBL18944010 | 0.77 | BRD4 (0.51) | ULK1BRD4 | |
| SCHEMBL18918783 | 0.76 | ULK1 (0.44) | CDK9CCNT1ULK1BTK | |
| SCHEMBL23912185 | 0.75 | ULK1 (0.42) | CDK9CCNT1ULK1BTKBRD4 | |
| SCHEMBL18944009 | 0.75 | CYP19A1 (0.46) | ULK1BRD4 | |
| SCHEMBL18944014 | 0.75 | ULK1 (0.42) | ULK1BTKBRD4 | |
| SCHEMBL18944017 | 0.75 | ULK1 (0.44) | ULK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938273-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2018-04-10 | — | — | US | disclosed |
| US-20170158690-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158690-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K11, MAP3K13, WEE2 | CDK9 293/4885CCNT1 1621/4885ULK1 495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.