Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 19/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18945889 | 0.90 | GLS (0.75) | GLSKCNH2 | |
| SCHEMBL20373637 | 0.86 | GLS (1.00) | GLSKCNH2 | |
| SCHEMBL18945962 | 0.83 | GLS (0.81) | GLSKCNH2 | |
| SCHEMBL17654174 | 0.83 | GLS (1.00) | GLS | |
| SCHEMBL17664624 | 0.83 | GLS (1.00) | GLS | |
| SCHEMBL17654173 | 0.83 | GLS (1.00) | GLS | |
| SCHEMBL28709845 | 0.82 | GLS (1.00) | GLS | |
| SCHEMBL29544070 | 0.82 | GLS (1.00) | GLS | |
| SCHEMBL18890304 | 0.82 | GLS (1.00) | GLS | |
| SCHEMBL22193574 | 0.81 | GLS (0.89) | GLSKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3383871-B1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-09-11 | — | — | EP | disclosed |
| WO-2017093300-A1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-06-08 | — | — | WO | disclosed |