Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 19/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.77 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | TACR1 | P25103 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373637 | 0.89 | GLS (1.00) | GLSKCNH2SLC6A2TACR1OPRM1 | |
| SCHEMBL22006876 | 0.88 | GLS (0.77) | GLSKCNH2SLC6A2TACR1OPRM1 | |
| SCHEMBL22006503 | 0.86 | KCNH2 (0.80) | GLSKCNH2 | |
| SCHEMBL31310106 | 0.86 | KCNH2 (0.80) | GLSKCNH2 | |
| SCHEMBL18946049 | 0.85 | GLS (0.85) | GLSKCNH2SLC6A2TACR1OPRM1 | |
| SCHEMBL20373216 | 0.85 | GLS (0.81) | GLSKCNH2 | |
| SCHEMBL29462506 | 0.85 | GLS (0.78) | GLSKCNH2SLC6A2TACR1OPRM1 | |
| SCHEMBL22193574 | 0.84 | GLS (0.89) | GLSKCNH2SLC6A2TACR1OPRM1 | |
| SCHEMBL18945357 | 0.83 | GLS (0.76) | GLSKCNH2 | |
| SCHEMBL29017117 | 0.82 | GLS (0.59) | GLSKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3383872-B1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | CANCER RESEARCH TECH LTD (GB) | 2020-05-20 | — | — | EP | disclosed |
| WO-2017093301-A1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-06-08 | — | — | WO | disclosed |