⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29693610 | 1.00 | — | — | |
| SCHEMBL6469996 | 0.89 | LMNA (0.42) | — | |
| SCHEMBL8199365 | 0.77 | — | — | |
| SCHEMBL148439 | 0.76 | — | — | |
| SCHEMBL29987888 | 0.76 | — | — | |
| SCHEMBL5576942 | 0.74 | ALDH1A1 (0.44) | — | |
| SCHEMBL5913947 | 0.74 | LMNA (0.38) | — | |
| SCHEMBL14834735 | 0.74 | KMT2A (0.41) | — | |
| SCHEMBL164463 | 0.73 | — | — | |
| SCHEMBL12892255 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1551 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119390656-B | Compound and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2025-04-08 | — | — | CN | claimed |
| CN-119390656-A | Compound and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2025-02-07 | — | — | CN | claimed |
| EP-3483166-B1 | IMIDAZOOXAZOLE DERIVATIVE HAVING ANTITUMOR EFFECT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | KOREA INST SCI & TECH (KR) | 2023-11-01 | — | — | EP | claimed |
| CN-109824602-B | Synthesis method of 4-chloro-2-methylthiopyrimidine | 南京哈柏医药科技有限公司 | 2023-10-27 | — | — | CN | claimed |
| CN-109694354-B | Synthesis method of 4-chloro-2-methylthiopyrimidine-5-ethyl formate | 南京哈柏医药科技有限公司 | 2023-10-24 | — | — | CN | claimed |
| EP-3658552-B1 | PROCESS FOR PREPARING N-(5-((4-(4-((DIMETHYLAMINO)METHYL)-3-PHENYL-1H-PYRAZOL-1-YL)PYRIMIDIN-2-YL)AMINO)-4-METHOXY-2-MORPHOLINOPHENYL)ACRYLAMIDE BY REACTING THE CORRESPONDING AMINE WITH A 3-HALO-PROPIONYL CHLORIDE | YUHAN CORP (KR) | 2023-09-13 | — | — | EP | claimed |
| CN-111315742-B | Process for preparing aminopyrimidine derivatives | 株式会社 柳韩洋行 | 2023-09-01 | — | — | CN | claimed |
| CN-116283793-A | Synthesis process of 2-methylthio-4-chloro-5-bromopyrimidine | 南京哈柏医药科技有限公司 | 2023-06-23 | — | — | CN | claimed |
| EP-3845539-B1 | IMIDAZOOXAZOLE DERIVATIVE HAVING ANTITUMOR EFFECT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | KOREA INST SCI & TECH (KR) | 2022-11-16 | — | — | EP | claimed |
| EP-3658553-B1 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF AMINOPYRIMIDINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES USING THE SAME | YUHAN CORP (KR) | 2022-06-15 | — | — | EP | claimed |
| EP-2283009-A1 | INHIBITORS OF JNK | F. Hoffmann-La Roche AG (CH) | 2011-02-16 | — | — | EP | claimed |
| US-20090318484-A1 | Inhibitors of JNK | ROCHE PALO ALTO LLC | 2009-12-24 | — | — | US | claimed |
| WO-2009138340-A1 | INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-19 | — | — | WO | claimed |
| US-20090215777-A1 | Pyrimidine Derivatives As HSP90 Inhibitors | ASTEX THERAPEUTICS LTD. (GB) | 2009-08-27 | — | — | US | claimed |
| EP-2049497-A2 | PYRIMIDINE DERIVATIVES AS HSP90 INHIBITORS | Astex Therapeutics Limited (GB) | 2009-04-22 | — | — | EP | claimed |
| CN-101339187-A | Methylsulfonyl miazines isotope labelling reagent, synthesis method and uses thereof | SHANGHAI INST ORGANIC CHEM (CN) | 2009-01-07 | — | — | CN | claimed |
| WO-2006123165-A2 | PYRIMIDINE DERIVATIVES AS HSP90 INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-11-23 | — | — | WO | claimed |
| CN-1130350-C | Process for preparing 4,6-dichloro-2-methiopyrimidine | SHAXING CHEMICAL CO LTD TAIZHO (CN) | 2003-12-10 | — | — | CN | claimed |
| CN-1396158-A | Process for synthesizing 4,6-dimethoxy-2-methiopyrimidine | UNIV ZHEJIANG POLYTECHNIC (CN) | 2003-02-12 | — | — | CN | claimed |
| CN-1343665-A | Process for preparing 4,6-dichloro-2-methiopyrimidine | SHAXING CHEMICAL CO LTD TAIZHO (CN) | 2002-04-10 | — | — | CN | claimed |