Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 3/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18952980 | 0.87 | PTGDR (0.34) | HRH3XDHAR | |
| SCHEMBL15536428 | 0.86 | CHRM2 (0.34) | HRH3AR | |
| SCHEMBL18952942 | 0.81 | GPR119 (0.40) | GPR119HRH3TBK1IKBKEXDH | |
| SCHEMBL30939598 | 0.81 | GPR119 (0.41) | GPR119HRH3TBK1IKBKEXDH | |
| SCHEMBL1979776 | 0.81 | GPR119 (0.41) | GPR119HRH3TBK1IKBKEXDH | |
| SCHEMBL30939577 | 0.80 | AR (0.43) | GPR119HRH3TBK1IKBKEXDH | |
| SCHEMBL1979888 | 0.80 | AR (0.43) | GPR119HRH3TBK1IKBKEXDH | |
| SCHEMBL22025246 | 0.79 | GPR119 (0.42) | GPR119HRH3TBK1IKBKEXDH | |
| SCHEMBL17354632 | 0.76 | AR (0.46) | GPR119HRH3TBK1IKBKEXDH | |
| SCHEMBL15536372 | 0.75 | OXTR (0.36) | HRH3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386506-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | Autifony Therapeutics Limited (GB) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017098254-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | AUTIFONY THERAPEUTICS LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |