Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | ESRRB | O95718 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESRRA | P11474 | 1/20 | 0.30 |
| ▸ | ESRRG | P62508 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.30 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15536372 | 0.88 | OXTR (0.36) | HRH3TRPV4MMP13ESRRAHSD11B1 | |
| SCHEMBL1979583 | 0.80 | ELANE (0.33) | ROCK2SRCSYKMAPK12HSD11B1 | |
| SCHEMBL19805319 | 0.80 | SRC (0.31) | SRCSYKMAPK12TRPV4ESRRB | |
| SCHEMBL18952974 | 0.80 | MMP13 (0.33) | ROCK2SRCSYKMAPK12TRPV4 | |
| SCHEMBL29437994 | 0.80 | ELANE (0.33) | ROCK2SRCSYKMAPK12HSD11B1 | |
| SCHEMBL18952970 | 0.78 | AR (0.36) | SRCSYKMAPK12TRPV4MMP13 | |
| SCHEMBL1979370 | 0.78 | ELANE (0.35) | TRPV4ESRRBESR1ESRRAESRRG | |
| SCHEMBL30939539 | 0.78 | ELANE (0.35) | TRPV4ESRRBESR1ESRRAESRRG | |
| SCHEMBL1979175 | 0.77 | AR (0.44) | SRCSYKMAPK12ESRRBESR1 | |
| SCHEMBL19011617 | 0.76 | AR (0.35) | ROCK2SRCSYKMAPK12HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386506-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | Autifony Therapeutics Limited (GB) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017098254-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | AUTIFONY THERAPEUTICS LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |