Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | ESRRB | O95718 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESRRA | P11474 | 1/20 | 0.30 |
| ▸ | ESRRG | P62508 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17554782 | 0.90 | KMT2A (0.33) | TRPV4ROCK2KMT2AELANEESRRB | |
| SCHEMBL18952970 | 0.90 | AR (0.36) | MMP13TRPV4SRCSYKMAPK12 | |
| SCHEMBL18952943 | 0.84 | PTGDR2 (0.37) | MMP13TRPV4HSD11B1HSD11B2AR | |
| SCHEMBL18953024 | 0.81 | AR (0.45) | MMP13ELANEESRRBESR1ESRRA | |
| SCHEMBL1979370 | 0.81 | ELANE (0.35) | TRPV4ELANEESRRBESR1ESRRA | |
| SCHEMBL30939539 | 0.81 | ELANE (0.35) | TRPV4ELANEESRRBESR1ESRRA | |
| SCHEMBL1979175 | 0.80 | AR (0.44) | KMT2ASRCSYKMAPK12ESRRB | |
| SCHEMBL18952957 | 0.80 | ROCK2 (0.31) | MMP13TRPV4ROCK2SRCSYK | |
| SCHEMBL18952947 | 0.79 | MMP13 (0.35) | MMP13TRPV4ROCK2ELANEHSD11B1 | |
| SCHEMBL18952946 | 0.79 | AR (0.36) | ESRRBESR1ESRRAESRRGESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386506-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | Autifony Therapeutics Limited (GB) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017098254-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | AUTIFONY THERAPEUTICS LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |