Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 2/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978597 | 0.87 | OXTR (0.36) | ALDH1A1NPSR1OXTRAVPR1AELANE | |
| SCHEMBL29437994 | 0.84 | ELANE (0.33) | NPSR1OXTRAVPR1AELANEHSD11B1 | |
| SCHEMBL1979583 | 0.84 | ELANE (0.33) | NPSR1OXTRAVPR1AELANEHSD11B1 | |
| SCHEMBL1978997 | 0.83 | PTGDR2 (0.38) | ELANEARKCNH2HRH3HSD11B1 | |
| SCHEMBL29438003 | 0.83 | PTGDR2 (0.38) | ELANEARKCNH2HRH3HSD11B1 | |
| SCHEMBL1981385 | 0.81 | SLC6A4 (0.33) | NPSR1HTR2ASLC6A4KCNH2 | |
| SCHEMBL30939565 | 0.81 | SLC6A4 (0.33) | NPSR1HTR2ASLC6A4KCNH2 | |
| SCHEMBL18952976 | 0.80 | HSD11B1 (0.34) | ELANEARSLC6A4KCNH2HSD11B1 | |
| SCHEMBL1980154 | 0.75 | IRAK4 (0.36) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL13828719 | 0.75 | NPSR1 (0.36) | KDM4EMEN1ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386506-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | Autifony Therapeutics Limited (GB) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017098254-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | AUTIFONY THERAPEUTICS LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |