Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18952954 | 0.91 | MMP13 (0.42) | MMP13SLC22A12HRH3HRH1AR | |
| SCHEMBL18952965 | 0.85 | MMP13 (0.38) | MMP13SLC22A12HRH3RET | |
| SCHEMBL18952943 | 0.84 | PTGDR2 (0.37) | MMP13HRH3AR | |
| SCHEMBL1984305 | 0.82 | SLC22A12 (0.37) | MMP13SLC22A12HRH3FNTAFNTB | |
| SCHEMBL30939605 | 0.82 | SLC22A12 (0.37) | MMP13SLC22A12HRH3FNTAFNTB | |
| SCHEMBL1978546 | 0.81 | AR (0.46) | MMP13SLC22A12HRH3HRH1AR | |
| SCHEMBL30939663 | 0.81 | AR (0.46) | MMP13SLC22A12HRH3HRH1AR | |
| SCHEMBL18952979 | 0.79 | MMP13 (0.41) | MMP13AR | |
| SCHEMBL1980470 | 0.78 | SLC22A12 (0.36) | MMP13SLC22A12HRH3HRH1RET | |
| SCHEMBL18952942 | 0.78 | GPR119 (0.40) | MMP13HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386506-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | Autifony Therapeutics Limited (GB) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017098254-A1 | MODULATORS OF KV3 CHANNELS TO TREAT PAIN | AUTIFONY THERAPEUTICS LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |