SCHEMBL18954635

SCHEMBL18954635

CCN1C(=O)C(=O)c2cccc(C(F)(F)F)c21

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.54
ALDH2 P05091 4/20 0.54
ALDH3A1 P30838 4/20 0.54
CHRM5 P08912 5/20 0.47
CHRM3 P20309 1/20 0.47
PARK7 Q99497 1/20 0.45
CES1 P23141 1/20 0.44
TNFRSF1A P19438 2/20 0.43
MAPT P10636 1/20 0.43
HTT P42858 1/20 0.43
HSD17B10 Q99714 1/20 0.43
CYP1B1 Q16678 3/20 0.42
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
KDM4E B2RXH2 1/20 0.40
LMNA P02545 1/20 0.40
USP2 O75604 1/20 0.40
ATM Q13315 1/20 0.40
KEAP1 Q14145 1/20 0.40
NFE2L2 Q16236 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18954670 0.88 ALDH1A1 (0.52) ALDH1A1ALDH2ALDH3A1CHRM5CHRM3
SCHEMBL28094096 0.85 ALDH1A1 (0.50) ALDH1A1ALDH2ALDH3A1CHRM5CHRM3
SCHEMBL25119457 0.84 ALDH1A1 (0.54) ALDH1A1ALDH2ALDH3A1CHRM5CHRM3
SCHEMBL4597041 0.84 ALDH1A1 (0.56) ALDH1A1ALDH2ALDH3A1CHRM5CHRM3
SCHEMBL27866582 0.81 ALDH1A1 (0.67) ALDH1A1ALDH2ALDH3A1CHRM5CHRM3
SCHEMBL18954689 0.81 CASP3 (0.55) ALDH1A1ALDH2ALDH3A1CHRM5CHRM3
SCHEMBL18954808 0.79 ALDH1A1 (0.58) ALDH1A1ALDH2ALDH3A1CHRM5CHRM3
SCHEMBL9175289 0.79 ALDH1A1 (0.59) ALDH1A1ALDH2ALDH3A1CHRM5CHRM3
SCHEMBL5001267 0.79 CHRM5 (0.60) ALDH1A1ALDH3A1CHRM5PARK7MAPT
SCHEMBL28256999 0.79 ALDH1A1 (0.67) ALDH1A1ALDH2ALDH3A1CHRM5CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105906544-B A kind of S type 3- hydroxyl -3- alkynyl oxidized indole compounds and its synthetic method and application 上海交通大学 2018-11-16 CN disclosed
WO-2017099695-A1 N-[(AMINOSULFONYL)PHENYL]-2-(1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)-HYDRAZINECARBOTHIOAMIDE DERIVATIVES FOR TREATING CANCER AND IMMUNOLOGICAL DISORDERS ISTANBUL UNIVERSITESI REKTORLUGU (TR) 2017-06-15 WO disclosed
CN-105906544-A S-type 3-hydroxy-3-alkynyloxoindole compound and synthetic method and application thereof 上海交通大学 2016-08-31 CN disclosed