Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | ALDH2 | P05091 | 5/20 | 0.56 |
| ▸ | ALDH3A1 | P30838 | 5/20 | 0.56 |
| ▸ | CES1 | P23141 | 2/20 | 0.55 |
| ▸ | CDC25A | P30304 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28094096 | 0.96 | ALDH1A1 (0.50) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL25119457 | 0.93 | ALDH1A1 (0.54) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL18954670 | 0.90 | ALDH1A1 (0.52) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL18954635 | 0.84 | ALDH1A1 (0.54) | ALDH1A1ALDH2ALDH3A1CES1MAPT | |
| SCHEMBL4597172 | 0.82 | ALDH1A1 (0.60) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL18954818 | 0.81 | ALDH1A1 (0.54) | ALDH1A1ALDH2ALDH3A1MAPTHPGD | |
| SCHEMBL3024396 | 0.81 | CDC25A (0.61) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL3025248 | 0.79 | ALDH1A1 (0.64) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL6283905 | 0.78 | ALDH1A1 (0.62) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL3023996 | 0.78 | CES1 (0.61) | ALDH1A1ALDH2ALDH3A1CES1CDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877378-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-01-16 | — | — | EP | disclosed |
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2007-05-10 | — | — | US | disclosed |
| WO-2006113864-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | OPRL1, OPRK1, TRPV1 | ALDH1A1 1136/4885ALDH2 720/4885ALDH3A1 1159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.