Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARK7 | Q99497 | 4/20 | 0.44 |
| ▸ | SMAD3 | P84022 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18954640 | 0.85 | ALDH1A1 (0.48) | SMAD3APAF1MAPTTP53ALDH1A1 | |
| SCHEMBL18954632 | 0.82 | PARK7 (0.43) | PARK7MAPTTP53ALDH1A1HSD17B10 | |
| SCHEMBL18954643 | 0.77 | SMAD3 (0.44) | SMAD3APAF1MAPTKDM1AALDH1A1 | |
| SCHEMBL18954621 | 0.77 | ALDH1A1 (0.40) | MAPTTP53ALDH1A1HSD17B10HTT | |
| SCHEMBL18954756 | 0.77 | KMT2A (0.40) | MAPTTP53ALDH1A1HSD17B10HTT | |
| SCHEMBL18954673 | 0.76 | ALDH1A1 (0.60) | MAPTTP53ALDH1A1HSD17B10HTT | |
| SCHEMBL9179332 | 0.75 | ALDH1A1 (0.62) | PARK7MAPTTP53ALDH1A1HSD17B10 | |
| SCHEMBL18954512 | 0.74 | ALDH1A1 (0.48) | MAPTTP53ALDH1A1HSD17B10HTT | |
| SCHEMBL18955259 | 0.73 | ALDH1A1 (0.47) | MAPTTP53ALDH1A1HSD17B10HTT | |
| SCHEMBL18954746 | 0.73 | PARK7 (0.52) | PARK7MAPTTP53ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017099695-A1 | N-[(AMINOSULFONYL)PHENYL]-2-(1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)-HYDRAZINECARBOTHIOAMIDE DERIVATIVES FOR TREATING CANCER AND IMMUNOLOGICAL DISORDERS | ISTANBUL UNIVERSITESI REKTORLUGU (TR) | 2017-06-15 | — | — | WO | disclosed |
| US-9150556-B2 | Benzimidazolone chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-06 | — | — | US | disclosed |