Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23888697 | 0.79 | LMNA (0.50) | GRM5SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL2715150 | 0.78 | GRM5 (0.46) | GRM5SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL8008287 | 0.78 | GRM5 (0.56) | GRM5SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL14238224 | 0.78 | NOTUM (0.52) | GRM5SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL2729506 | 0.78 | GRM5 (0.46) | GRM5SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL27150414 | 0.77 | ADRB1 (0.49) | GRM5SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL3462062 | 0.74 | LMNA (0.57) | GRM5SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL9521570 | 0.74 | SMN1; SMN2 (0.67) | GRM5SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL25301995 | 0.74 | LOXL2 (0.54) | GRM5SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL21423380 | 0.74 | GRM5 (0.46) | GRM5SMN1; SMN2HTTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964534-B2 | Nuclear magnetic resonance assembly of chemical entities using advanced antenna probes | TRIAD LIQUIDATING COMPANY, LLC (US) | 2011-06-21 | — | — | US | disclosed |
| US-20110118148-A1 | NUCLEAR MAGNETIC RESONANCE ASSEMBLY OF CHEMICAL ENTITIES USING ADVANCED ANTENNA PROBES | TRIAD LIQUIDATING COMPANY, LLC | 2011-05-19 | — | — | US | disclosed |
| EP-1611425-A2 | NUCLEAR MAGNETIC RESONANCE ASSEMBLY OF CHEMICAL ENTITIES USING ADVANCED ANTENNA PROBES | Triad Therapeutics, Inc. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004083814-A2 | NUCLEAR MAGNETIC RESONANCE ASSEMBLY OF CHEMICAL ENTITIES USING ADVANCED ANTENNA PROBES | TRIAD THERAPEUTICS, INC. (US) | 2004-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118148-A1 | NUCLEAR MAGNETIC RESONANCE ASSEMBLY OF CHEMICAL ENTITIES USING ADVANCED ANTENNA PROBES | AURKAIP1, MRPS27, ATRIP | GRM5 1086/4885SMN1; SMN2 4598/4885HTT 3679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.