SCHEMBL18964489

SCHEMBL18964489

Cc1ccc(N2CCCC(NC(=O)OC(C)(C)C)C2=O)cn1

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.46
FPR2 P25090 16/20 0.44
FPR1 P21462 12/20 0.44
MMP1 P03956 1/20 0.42
F2 P00734 1/20 0.40
F10 P00742 1/20 0.40
PRSS1 P07477 1/20 0.40
CKS1B P61024 1/20 0.40
SKP1 P63208 1/20 0.40
SKP2 Q13309 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18291719 0.89 FPR2 (0.43) FPR2FPR1F2F10PRSS1
SCHEMBL22179924 0.89 FPR2 (0.45) FPR2FPR1
SCHEMBL29462396 0.89 FPR2 (0.43) FPR2FPR1F2F10PRSS1
SCHEMBL18964487 0.88 FPR2 (0.43) FPR2FPR1F2F10PRSS1
SCHEMBL30133740 0.88 FPR2 (0.43) FPR2FPR1F2F10PRSS1
SCHEMBL18964488 0.88 FPR2 (0.43) FPR2FPR1F2F10PRSS1
SCHEMBL30133743 0.88 FPR2 (0.43) FPR2FPR1F2F10PRSS1
SCHEMBL28377662 0.88 FPR2 (0.43) FPR2FPR1F2F10PRSS1
SCHEMBL18291706 0.86 FPR2 (0.42) FPR2FPR1MMP1F2F10
SCHEMBL22179954 0.83 FPR2 (0.64) FPR2FPR1CKS1BSKP1SKP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017100390-A1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2017-06-15 WO disclosed