Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23229067 | 0.77 | BCAT2 (0.42) | LMNABCAT2HPGDMAPTNPC1 | |
| SCHEMBL15519705 | 0.67 | LMNA (0.45) | LMNABCAT2HPGDMAPTNPC1 | |
| SCHEMBL13833647 | 0.67 | LMNA (0.49) | LMNABCAT2HPGDMAPTNPC1 | |
| SCHEMBL18964871 | 0.66 | MAPT (0.39) | LMNABCAT2HPGDMAPTMAP2K1 | |
| SCHEMBL25018746 | 0.65 | BCAT2 (0.47) | LMNABCAT2HPGDMAPTNPC1 | |
| SCHEMBL15519349 | 0.64 | ADORA2A (0.41) | LMNABCAT2HPGDMAP2K1MAPK1 | |
| SCHEMBL9731545 | 0.62 | ADORA2A (0.35) | LMNABCAT2HPGDMAPTALDH1A1 | |
| SCHEMBL15520411 | 0.62 | CHEK1 (0.42) | LMNABCAT2HPGDMAPTRAB9A | |
| SCHEMBL2950082 | 0.61 | ALDH1A1 (0.62) | LMNAHPGDMAPTMEN1KMT2A | |
| SCHEMBL17950462 | 0.61 | ALDH1A1 (0.59) | LMNAHPGDMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386591-B1 | HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF | CADENT THERAPEUTICS INC (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2017100591-A1 | HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF | LUC THERAPEUTICS (US) | 2017-06-15 | — | — | WO | disclosed |