Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | NPFFR2 | Q9Y5X5 | 3/20 | 0.41 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22146212 | 0.85 | HTR3E (0.34) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL18964856 | 0.78 | MPL (0.37) | NOTUMGRM4 | |
| SCHEMBL8042030 | 0.73 | HSD17B10 (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL29642223 | 0.72 | TRPV1 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL364052 | 0.72 | TRPV1 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL22509494 | 0.72 | RAPGEF4 (0.34) | RAPGEF4 | |
| SCHEMBL19523877 | 0.72 | AR (0.56) | — | |
| SCHEMBL2698021 | 0.72 | NOTUM (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL29649700 | 0.72 | IDO1 (0.50) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL987352 | 0.72 | IDO1 (0.50) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386591-B1 | HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF | CADENT THERAPEUTICS INC (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2017100591-A1 | HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF | LUC THERAPEUTICS (US) | 2017-06-15 | — | — | WO | disclosed |