Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.33 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14140382 | 0.82 | KMT2A (0.42) | RAPGEF4MAPTSLC2A1ALDH1A1MEN1 | |
| SCHEMBL8042030 | 0.78 | HSD17B10 (0.46) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL10187271 | 0.78 | CES2 (0.41) | — | |
| SCHEMBL16229877 | 0.74 | CA1 (0.54) | MAPK1HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL21417380 | 0.73 | ALDH1A1 (0.50) | HSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL14135197 | 0.73 | MCL1 (0.38) | MAPTSLC6A3TTRHSD17B10ALDH1A1 | |
| SCHEMBL25559544 | 0.73 | — | — | |
| SCHEMBL22781556 | 0.73 | MAP4K4 (0.40) | MAPTHSD17B10ALDH1A1TSHRTDP1 | |
| SCHEMBL13191461 | 0.73 | HDAC1 (0.41) | MAPTKMOHSD17B10ALDH1A1MEN1 | |
| SCHEMBL18964945 | 0.72 | HTR3E (0.47) | RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3766885-B1 | TRICYCLIC COMPOUNDS AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | PFIZER (US) | 2022-05-25 | — | — | EP | disclosed |
| WO-2021238587-A1 | MICROMOLECULAR OXATHIAZINE DERIVATIVE AND USE THEREOF | 四川大学华西医院 | 2021-12-02 | — | — | WO | disclosed |
| EP-3766885-A1 | TRICYCLIC COMPOUNDS AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | Pfizer Inc (US) | 2021-01-20 | — | — | EP | disclosed |
| EP-3310784-B1 | TRICYCLIC COMPOUNDS AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS. | PFIZER (US) | 2020-10-07 | — | — | EP | disclosed |