Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18970603 | 0.80 | MAP4K4 (0.60) | DYRK1BCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL29729443 | 0.70 | LMNA (0.58) | CYP1A2MAPK1LMNAKDM4E | |
| SCHEMBL282245 | 0.70 | LMNA (0.58) | CYP1A2MAPK1LMNAKDM4E | |
| SCHEMBL31121065 | 0.70 | PIK3CA (0.59) | DYRK1BTGFBR1CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL15638169 | 0.69 | DOT1L (0.48) | DYRK1BDOT1LCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27695762 | 0.68 | HPGD (0.44) | DYRK1BCLK4TSHRALDH1A1CTSA | |
| SCHEMBL27415512 | 0.68 | IKBKB (0.41) | TLR8CLK4TSHRMAPK1CTSA | |
| SCHEMBL27469863 | 0.68 | DYRK1B (0.43) | DYRK1BTLR8TSHRALDH1A1MAPK1 | |
| SCHEMBL17194888 | 0.67 | CLK4 (0.43) | TLR8CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4758609 | 0.67 | LMNA (0.56) | DYRK1BCYP1A2CYP2C19ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3388420-B1 | QUINOLINE COMPOUNDS, PREPARATION METHOD THEREOF, AND USE THEREOF AS URATE TRANSPORTER INHIBITOR DRUG | HINOVA PHARMACEUTICALS INC (CN) | 2022-06-22 | — | — | EP | disclosed |
| WO-2017097182-A1 | QUINOLINE COMPOUNDS, PREPARATION METHOD THEREOF, AND USE THEREOF AS URATE TRANSPORTER INHIBITOR DRUG | 成都海创药业有限公司 | 2017-06-15 | — | — | WO | disclosed |