Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897112 | 0.81 | SMN1; SMN2 (0.46) | GAAPOLBNAMPTSMN1; SMN2MAPT | |
| SCHEMBL6171950 | 0.80 | HSD17B3 (0.36) | GAASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL6173888 | 0.76 | HSD17B3 (0.35) | ALDH1A1MEN1MAPTKMT2ANPC1 | |
| SCHEMBL10370451 | 0.67 | MAOA (0.35) | LMNASMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL5349459 | 0.65 | GAA (0.71) | GAAPOLBSMN1; SMN2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL17559456 | 0.64 | GAA (0.69) | GAAPOLBSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL27529391 | 0.63 | MAOA (0.31) | — | |
| SCHEMBL76489 | 0.63 | ALDH1A1 (0.67) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6474890 | 0.62 | GAA (0.96) | GAAPOLBRECQLSMN1; SMN2ALOX5 | |
| SCHEMBL10509926 | 0.61 | NOTUM (0.56) | GAAPOLBRECQLLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947833-B2 | methods that are useful in the preparation of amidophenyl-sulfonylamino-quinoxaline compounds CCK2 modulators are disclosed by sulfonylation | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-24 | — | — | US | disclosed |