Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.32 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10576926 | 0.78 | MAOA (0.35) | MAOAMAOBHSD17B3TSHRSMN1; SMN2 | |
| SCHEMBL10372476 | 0.75 | SIGMAR1 (0.32) | — | |
| SCHEMBL10371070 | 0.75 | RIPK1 (0.35) | — | |
| SCHEMBL10370618 | 0.72 | LMNA (0.33) | TSHRDRD2DRD1DRD3SMN1; SMN2 | |
| SCHEMBL6171950 | 0.72 | HSD17B3 (0.36) | MAOAMAOBHSD17B3TSHRSMN1; SMN2 | |
| SCHEMBL30025878 | 0.71 | MEN1 (0.42) | HSD17B3SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL6173888 | 0.70 | HSD17B3 (0.35) | HSD17B3TSHRSLC6A2SLC6A4MEN1 | |
| SCHEMBL10370437 | 0.69 | KDM4E (0.38) | TSHRTDP1MAPTKDM4E | |
| SCHEMBL4139022 | 0.69 | MAOA (0.44) | MAOAMAOBHSD17B3TSHRSLC6A2 | |
| SCHEMBL5530904 | 0.69 | MAOA (0.41) | MAOAMAOBHSD17B3TSHRSETD7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107930-B1 | FUSED AROMATIC OXAZEPINONES AND SULPHUR ANALOGUES THEREOF AND THEIR PREPARATION AND USE IN COUNTERACTING HISTAMINE | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1990-11-28 | — | — | EP | claimed |