Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18255998 | 0.85 | MRGPRX4 (0.52) | MRGPRX4HSD17B10CYP1A2CYP2C19MAPT | |
| SCHEMBL9047880 | 0.84 | MRGPRX4 (0.58) | MRGPRX4HSD17B10CYP1A2CYP2C19MAPT | |
| SCHEMBL8145313 | 0.84 | MRGPRX4 (0.51) | MRGPRX4HSD17B10CYP1A2CYP2C19MAPT | |
| SCHEMBL10644438 | 0.84 | MRGPRX4 (0.55) | MRGPRX4HSD17B10CYP1A2CYP2C19MAPT | |
| SCHEMBL10641694 | 0.84 | MRGPRX4 (0.51) | MRGPRX4HSD17B10CYP1A2CYP2C19MAPT | |
| SCHEMBL5243287 | 0.84 | MRGPRX4 (0.51) | MRGPRX4HSD17B10CYP1A2CYP2C19MAPT | |
| SCHEMBL10644274 | 0.84 | MRGPRX4 (0.58) | MRGPRX4HSD17B10CYP1A2CYP2C19MAPT | |
| SCHEMBL345384 | 0.82 | TP53 (0.48) | HSD17B10CYP1A2CYP2C19MAPTTP53 | |
| SCHEMBL28069664 | 0.81 | SMN1; SMN2 (0.50) | MRGPRX4HSD17B10CYP1A2CYP2C19MAPT | |
| SCHEMBL1225966 | 0.81 | ALDH1A1 (0.59) | HSD17B10MAPTTP53MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3388433-B1 | PHTHALAZINE DERIVATIVES, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI SIMR BIOTECH CO LTD (CN) | 2023-08-30 | — | — | EP | disclosed |
| US-20200190507-A1 | Encoded Solid Phase Compound Library with Polynucleotide Based Barcoding | SCRIPPS RESEARCH INST (US) | 2020-06-18 | — | — | US | disclosed |
| US-20200190507-A1 | Encoded Solid Phase Compound Library with Polynucleotide Based Barcoding | SCRIPPS RESEARCH INST (US) | 2020-06-18 | — | — | US | disclosed |
| EP-3538669-A2 | ENCODE SOLID PHASE COMPOUND LIBRARY WITH POLYNUCLEOTIDE BASED BARCODING | The Scripps Research Institute (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089641-A2 | ENCODE SOLID PHASE COMPOUND LIBRARY WITH POLYNUCLEOTIDE BASED BARCODING | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2017097217-A1 | PHTHALAZINE DERIVATIVES, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 上海赛默罗生物科技有限公司 | 2017-06-15 | — | — | WO | disclosed |