Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 5/20 | 0.38 |
| ▸ | IL1B | P01584 | 3/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20169760 | 0.84 | CRBN (0.53) | TNFIL1BCRBNIKZF1DDB1 | |
| SCHEMBL18975490 | 0.81 | CRBN (0.51) | TNFIL1BCRBNIKZF1DDB1 | |
| SCHEMBL2249883 | 0.78 | EPHB4 (0.39) | TNFIL1BCRBNIKZF1DDB1 | |
| SCHEMBL20880770 | 0.76 | CRBN (0.54) | TNFIL1BCRBNIKZF1DDB1 | |
| SCHEMBL19069052 | 0.74 | POLB (0.41) | TNFIL1BCRBNIKZF1DDB1 | |
| SCHEMBL2247902 | 0.73 | CRBN (0.72) | TNFIL1BCRBNIKZF1DDB1 | |
| SCHEMBL23934591 | 0.73 | PTGS2 (0.42) | — | |
| SCHEMBL23739743 | 0.73 | HTR2A (0.33) | CRBNIKZF3SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL18975818 | 0.73 | CRBN (0.34) | TNFIL1BCRBNIKZF1DDB1 | |
| SCHEMBL16768202 | 0.72 | CRBN (0.61) | TNFIL1BCRBNIKZF1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536706-B1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2017-06-14 | — | — | EP | disclosed |