Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.34 |
| ▸ | IKZF3 | Q9UKT9 | 10/20 | 0.34 |
| ▸ | TNF | P01375 | 4/20 | 0.34 |
| ▸ | IL1B | P01584 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18975490 | 0.80 | CRBN (0.51) | CRBNIKZF3TNFIL1BSMN1; SMN2 | |
| SCHEMBL20169760 | 0.79 | CRBN (0.53) | CRBNIKZF3TNFIL1BSMN1; SMN2 | |
| SCHEMBL2250443 | 0.79 | PKM (0.39) | CRBNIKZF3TNFIL1BSMN1; SMN2 | |
| SCHEMBL19069052 | 0.74 | POLB (0.41) | CRBNIKZF3TNFIL1BSMN1; SMN2 | |
| SCHEMBL12372050 | 0.74 | CRBN (0.66) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL16768199 | 0.73 | CRBN (0.56) | CRBNIKZF3TNFIL1BIKZF1 | |
| SCHEMBL19222088 | 0.73 | MAPT (0.33) | SMN1; SMN2PKMMAPTLMNAALDH1A1 | |
| SCHEMBL18975485 | 0.73 | TNF (0.38) | CRBNIKZF3TNFIL1BSMN1; SMN2 | |
| SCHEMBL20880770 | 0.72 | CRBN (0.54) | CRBNIKZF3TNFIL1BSMN1; SMN2 | |
| SCHEMBL23739743 | 0.72 | HTR2A (0.33) | CRBNIKZF3SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3599236-B1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-3202460-B1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2019-06-12 | — | — | EP | disclosed |
| EP-3106460-B1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-2536706-B1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2017-06-14 | — | — | EP | disclosed |