Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23740007 | 0.85 | MAPT (0.34) | ABCB1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL23739741 | 0.83 | ALDH1A1 (0.32) | HTR2AHTR2CHTR2BABCB1ALDH1A1 | |
| SCHEMBL19069052 | 0.83 | POLB (0.41) | CRBNIKZF3HTTPOLBRECQL | |
| SCHEMBL23739663 | 0.81 | MAPT (0.48) | HTTPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL19069020 | 0.80 | CRBN (0.38) | PARP1CRBNMEN1KMT2AALOX15 | |
| SCHEMBL23739693 | 0.79 | HTR1A (0.44) | HTR2AABCB1 | |
| SCHEMBL23739846 | 0.79 | ALDH1A1 (0.35) | HTR2CTRPM2PARP1ABCB1ALDH1A1 | |
| SCHEMBL23739841 | 0.79 | MAPT (0.53) | HTTPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL20169760 | 0.78 | CRBN (0.53) | CRBNIKZF3HTTALDH1A1L3MBTL1 | |
| SCHEMBL20631262 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |