Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20863100 | 0.79 | HSD17B1 (0.38) | HSD17B1HSD17B2STSGPBAR1ESR1 | |
| SCHEMBL19155482 | 0.76 | JAK2 (0.36) | JAK2BTK | |
| SCHEMBL29782721 | 0.73 | BTK (0.40) | JAK2BTK | |
| SCHEMBL17699662 | 0.73 | BTK (0.40) | JAK2BTK | |
| SCHEMBL29709653 | 0.69 | BTK (0.40) | JAK2BTKHSD17B1HSD17B2 | |
| SCHEMBL16336718 | 0.69 | BTK (0.40) | JAK2BTKHSD17B1HSD17B2 | |
| SCHEMBL16183639 | 0.69 | JAK2 (0.51) | JAK2BTK | |
| SCHEMBL9796594 | 0.68 | KMT2A (0.42) | ESR1ESR2 | |
| SCHEMBL3712017 | 0.68 | JAK2 (0.34) | JAK2BTK | |
| SCHEMBL21805777 | 0.68 | MEN1 (0.36) | JAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013814-B1 | SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-06-14 | — | — | EP | disclosed |