Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.31 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16336718 | 1.00 | BTK (0.40) | BTKGRM4ALDH1A1HSD17B1HSD17B2 | |
| SCHEMBL16337053 | 0.77 | BTK (0.43) | BTKGRM4 | |
| SCHEMBL29709486 | 0.77 | BTK (0.43) | BTKGRM4 | |
| SCHEMBL17699662 | 0.73 | BTK (0.40) | BTKJAK2 | |
| SCHEMBL29782721 | 0.73 | BTK (0.40) | BTKJAK2 | |
| SCHEMBL18976231 | 0.69 | JAK2 (0.37) | BTKHSD17B1HSD17B2JAK2 | |
| SCHEMBL16320402 | 0.69 | POLB (0.40) | ALDH1A1KMT2A | |
| SCHEMBL18985009 | 0.66 | JAK2 (0.35) | BTKALDH1A1JAK2LPLLIPG | |
| SCHEMBL11927624 | 0.66 | LPL (0.44) | BTKJAK2LPLLIPG | |
| SCHEMBL16336876 | 0.66 | GRM4 (0.45) | BTKGRM4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4008328-A1 | PRIMARY CARBOXAMIDES AS BTK INHIBITORS | AbbVie Inc. (US) | 2022-06-08 | — | — | EP | disclosed |