Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18757720 | 0.91 | CYP3A4 (0.39) | TDP1ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL6024930 | 0.78 | ALDH1A1 (0.49) | HPGDTDP1ALDH1A1GAAKDM4E | |
| SCHEMBL20291230 | 0.77 | EPHX1 (0.41) | HPGDTDP1ALDH1A1GAAKDM4E | |
| SCHEMBL1111756 | 0.76 | ALDH1A1 (0.46) | HPGDTDP1ALDH1A1GAAKDM4E | |
| SCHEMBL22436130 | 0.74 | LMNA (0.48) | KDM4EMAPTRAB9AKMT2ALMNA | |
| SCHEMBL29922322 | 0.72 | KDM4E (0.50) | TDP1ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL21799663 | 0.72 | KDM4E (0.50) | TDP1ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL13439362 | 0.71 | EPHX1 (0.36) | HPGDTDP1ALDH1A1GAAMAPT | |
| SCHEMBL15928723 | 0.69 | KDM4E (0.48) | TDP1ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL19063494 | 0.69 | MAPT (0.42) | HPGDTDP1ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019493-B1 | MODIFIED BET-PROTEIN INHIBITING DIHYDROCHINOXALINONES AND DIHYDROPYRIDOPYRAZINONES | Bayer Pharma AG (DE) | 2017-06-14 | — | — | EP | disclosed |