Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | ANO1 | Q5XXA6 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1953935 | 0.96 | CASP3 (0.53) | SMN1; SMN2TP53CASP3SENP8SENP7 | |
| SCHEMBL1952338 | 0.92 | SMN1; SMN2 (0.53) | SMN1; SMN2TP53CASP3SENP8SENP7 | |
| SCHEMBL1897754 | 0.91 | ALDH1A1 (0.49) | SMN1; SMN2TP53CASP3SENP8SENP7 | |
| SCHEMBL1954819 | 0.87 | MEN1 (0.56) | SMN1; SMN2TP53CASP3SENP8SENP7 | |
| SCHEMBL15241643 | 0.87 | TP53 (0.46) | SMN1; SMN2TP53CASP3SENP8SENP7 | |
| SCHEMBL1953704 | 0.87 | ANO1 (0.59) | SMN1; SMN2TP53ANO1ANO2 | |
| SCHEMBL1952289 | 0.85 | ANO1 (0.57) | SMN1; SMN2TP53CASP3SENP8SENP7 | |
| SCHEMBL12271436 | 0.85 | CASP3 (0.67) | SMN1; SMN2CASP3SENP8SENP7SENP6 | |
| SCHEMBL12271561 | 0.83 | MEN1 (0.53) | SMN1; SMN2TP53CASP3SENP8SENP7 | |
| SCHEMBL1951947 | 0.83 | ANO1 (0.53) | SMN1; SMN2TP53CASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321303-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010027875-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2010-03-11 | — | — | WO | disclosed |