Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26304706 | 0.94 | POLB (0.43) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL18977640 | 0.79 | POLB (0.35) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL23624594 | 0.77 | CASP3 (0.51) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL1516119 | 0.75 | CASP3 (0.50) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL19485443 | 0.75 | CASP3 (0.50) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL15934131 | 0.72 | POLB (0.47) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL24092042 | 0.72 | POLB (0.47) | POLBCASP3SENP7SENP6NPC1 | |
| SCHEMBL18977638 | 0.72 | CHRNA7 (0.36) | — | |
| SCHEMBL18978014 | 0.71 | S1PR4 (0.33) | CYP2C9CYP2C19S1PR1 | |
| SCHEMBL23578374 | 0.71 | NPC1 (0.47) | POLBCASP3SENP7SENP6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2703392-B1 | 5-MEMBERED RING AROMATIC HETEROCYCLIC DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | SHIONOGI & CO (JP) | 2017-06-14 | — | — | EP | disclosed |