Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 10/20 | 0.49 |
| ▸ | CA2 | P00918 | 10/20 | 0.49 |
| ▸ | CA9 | Q16790 | 8/20 | 0.49 |
| ▸ | CA12 | O43570 | 7/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PPM1B | O75688 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.34 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31715807 | 1.00 | CA1 (0.49) | CA1CA2CA9CA12TRPA1 | |
| SCHEMBL19513106 | 0.89 | CA1 (0.47) | CA1CA2CA9CA12TRPA1 | |
| SCHEMBL17670684 | 0.89 | CA1 (0.47) | CA1CA2CA9CA12TRPA1 | |
| SCHEMBL13868767 | 0.85 | CA1 (0.51) | CA1CA2CA9CA12TRPA1 | |
| SCHEMBL13201071 | 0.85 | CA1 (0.51) | CA1CA2CA9CA12TRPA1 | |
| SCHEMBL18202965 | 0.85 | CA1 (0.48) | CA1CA2CA9CA12ALDH1A1 | |
| SCHEMBL15805069 | 0.85 | CA1 (0.48) | CA1CA2CA9CA12ALDH1A1 | |
| SCHEMBL1898822 | 0.85 | CA1 (0.51) | CA1CA2CA9CA12TRPA1 | |
| SCHEMBL28741168 | 0.83 | CA1 (0.47) | CA1CA2CA9CA12TRPA1 | |
| SCHEMBL26952470 | 0.83 | CA1 (0.47) | CA1CA2CA9CA12TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498605-B1 | DIURETICS | MERCK SHARP & DOHME (US) | 2014-08-27 | — | — | EP | disclosed |
| US-8354394-B2 | Diuretics | MERCK SHARP & DOHME CORP. (US) | 2013-01-15 | — | — | US | disclosed |
| EP-2498605-A1 | DIURETICS | Merck Sharp & Dohme Corp. (US) | 2012-09-19 | — | — | EP | disclosed |
| US-20120208838-A1 | DIURETICS | MERCK SHARP & DOHME LLC | 2012-08-16 | — | — | US | disclosed |
| WO-2011053519-A1 | DIURETICS | MERCK SHARP & DOHME CORP. (US) | 2011-05-05 | — | — | WO | disclosed |
| EP-0683781-B1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | METABASIS THERAPEUTICS INC (US) | 2004-04-21 | — | — | EP | disclosed |
| US-5731432-A | Inhibitors of adenosine monophosphate deaminase | GENSIA SICOR INC. (US) | 1998-03-24 | — | — | US | disclosed |
| EP-0683781-A4 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE. | GENSIA PHARMA (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0683781-A1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | GENSIA PHARMACEUTICALS, INC. (US) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994018200-A1 | NOVEL INHIBITORS OF ADENOSINE MONOPHOSPHATE DEAMINASE | GENSIA, INC. (US) | 1994-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208838-A1 | DIURETICS | REN, AGTR1, AGTR2 | CA1 1651/4885CA2 131/4885CA9 328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.