Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9855895 | 0.79 | NPSR1 (0.51) | TSHRCA1CA2TDP1MAPT | |
| SCHEMBL15441153 | 0.78 | TSHR (0.57) | TSHRCA1CA2CA12CA9 | |
| SCHEMBL6950525 | 0.77 | TSHR (0.55) | TSHRCA1CA2CA12CA9 | |
| SCHEMBL11187331 | 0.77 | TSHR (0.55) | TSHRCA1CA2CA12CA9 | |
| SCHEMBL11187333 | 0.77 | TSHR (0.55) | TSHRCA1CA2CA12CA9 | |
| SCHEMBL1185858 | 0.76 | SMN1; SMN2 (0.49) | MAPTL3MBTL1RAB9AALDH1A1GAA | |
| SCHEMBL16682784 | 0.76 | SRC (0.46) | TSHRCA1CA2CA12CA9 | |
| SCHEMBL517908 | 0.76 | ATM (0.44) | L3MBTL1ALDH1A1ATM | |
| SCHEMBL4630315 | 0.76 | SRC (0.46) | TSHRCA1CA2CA12CA9 | |
| SCHEMBL66018 | 0.75 | L3MBTL1 (0.61) | TDP1L3MBTL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935713-B2 | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. (US) | 2011-05-03 | — | — | US | disclosed |