Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL18979874 | 1.00 | PRKCI (0.37) | PRKCITHRBRECQLTDP1MAPT | |
| SCHEMBL33767 | 0.98 | PRKCI (0.38) | PRKCITHRBRECQLTDP1MAPT | |
| SCHEMBL29378444 | 0.98 | PRKCI (0.38) | PRKCITHRBRECQLTDP1MAPT | |
| Water SCHEMBL28619662 | 0.96 | PRKCI (0.37) | PRKCITHRBRECQLTDP1MAPT | |
| Hydrochloric Acid SCHEMBL5200042 | 0.96 | THRB (0.41) | PRKCITHRBRECQLTDP1MAPT | |
| Hydrochloric Acid SCHEMBL29836023 | 0.96 | THRB (0.41) | PRKCITHRBRECQLTDP1MAPT | |
| Hydrochloric Acid SCHEMBL7162451 | 0.96 | THRB (0.41) | PRKCITHRBRECQLTDP1MAPT | |
| SCHEMBL8441723 | 0.92 | PRKCI (0.35) | PRKCITHRBRECQLTDP1MAPT | |
| Sulfuric Acid SCHEMBL672183 | 0.88 | ALDH1A1 (0.52) | PRKCITHRBRECQLTDP1MAPT | |
| Sulfuric Acid SCHEMBL29836019 | 0.88 | ALDH1A1 (0.52) | PRKCITHRBRECQLTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10376454-B2 | Products for the oxidative dyeing of hair in copper shades with improved gray coverage | HENKEL AG & CO. KGAA (DE) | 2019-08-13 | — | — | US | disclosed |
| US-10034822-B2 | Fashionable copper shades in a nonionic base | HENKEL AG & CO. KGAA (DE) | 2018-07-31 | — | — | US | disclosed |
| US-20180140524-A1 | PRODUCTS FOR THE OXIDATIVE DYEING OF HAIR IN COPPER SHADES WITH IMPROVED GRAY COVERAGE | HENKEL AG & CO. KGAA (DE) | 2018-05-24 | — | — | US | disclosed |
| US-20170172882-A1 | FASHIONABLE COPPER SHADES IN A NONIONIC BASE | HENKEL AG & CO. KGAA (DE) | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180140524-A1 | PRODUCTS FOR THE OXIDATIVE DYEING OF HAIR IN COPPER SHADES WITH IMPROVED GRAY COVERAGE | AOC1, TYR, COXFA4L2 | ACHE 1534/4885PRKCI 3425/4885THRB 2469/4885 |
| US-10376454-B2 | Products for the oxidative dyeing of hair in copper shades with improved gray coverage | AOC1, TYR, COXFA4L2 | ACHE 1534/4885PRKCI 3425/4885THRB 2469/4885 |
| US-20170172882-A1 | FASHIONABLE COPPER SHADES IN A NONIONIC BASE | KRT18, AOC1, PRKDC | ACHE 3103/4885PRKCI 1827/4885THRB 2903/4885 |
| US-10034822-B2 | Fashionable copper shades in a nonionic base | KRT18, AOC1, PRKDC | ACHE 3103/4885PRKCI 1827/4885THRB 2903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.