Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8062327 | 0.93 | MAPT (0.49) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL14915780 | 0.86 | ALDH1A1 (0.46) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL4103425 | 0.85 | MAPT (0.49) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL3294994 | 0.85 | ALDH1A1 (0.59) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL29738113 | 0.83 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL2944676 | 0.83 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL31077653 | 0.83 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL2911207 | 0.83 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL20511707 | 0.82 | ALDH1A1 (0.46) | ALDH1A1TDP1MAPTCYP3A4KDM4E | |
| SCHEMBL30267712 | 0.82 | ALDH1A1 (0.46) | ALDH1A1TDP1MAPTCYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4650351-A1 | INHIBITOR OF COMPLEMENT FACTOR B | Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. (CN) | 2025-11-19 | — | — | EP | disclosed |
| CN-120717897-A | Synthesis method of aromatic intermediate 1-bromo-2-methoxy-4-methyl-5-nitrobenzene | 常州大学 | 2025-09-30 | — | — | CN | disclosed |
| CN-120717897-A | Synthesis method of aromatic intermediate 1-bromo-2-methoxy-4-methyl-5-nitrobenzene | 常州大学 | 2025-09-30 | — | — | CN | disclosed |
| EP-4523755-A2 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | F. Hoffmann-La Roche AG (CH) | 2025-03-19 | — | — | EP | disclosed |
| US-12234244-B2 | Substituted piperazines as inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2025-02-25 | — | — | US | disclosed |
| EP-4360713-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | HOFFMANN LA ROCHE (CH) | 2024-10-30 | — | — | EP | disclosed |
| US-20240352028-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC (US) | 2024-10-24 | — | — | US | disclosed |
| WO-2024149261-A1 | INHIBITOR OF COMPLEMENT FACTOR B | 南京正大天晴制药有限公司 | 2024-07-18 | — | — | WO | disclosed |
| CN-118255772-A | Quinazoline derivatives as antitumor agents | 苏州赞荣医药科技有限公司 | 2024-06-28 | — | — | CN | disclosed |
| WO-2024099458-A1 | PIPERIDINE-SUBSTITUTED BENZOIC ACID COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 上海医药工业研究院有限公司 | 2024-05-16 | — | — | WO | disclosed |
| WO-2015054572-A1 | INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC (US) | 2015-04-16 | — | — | WO | disclosed |
| US-20140323730-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER (US) | 2014-10-30 | — | — | US | disclosed |
| US-8802688-B2 | Substituted acetyl-coa carboxylase inhibitors | PFIZER INC. (US) | 2014-08-12 | — | — | US | disclosed |
| EP-2699576-A1 | PYRAZOLOSPIROKETONE DERIVATIVES FOR USE AS ACETYL - COA CARBOXYLASE INHIBITORS | Pfizer Inc (US) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143813-A1 | PYRAZOLOSPIROKETONE DERIVATIVES FOR USE AS ACETYL - COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-10-26 | — | — | WO | disclosed |
| US-20120270893-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-10-25 | — | — | US | disclosed |
| CN-102718692-A | Preparation method of 7-bit methyl-5-bit oxygen-substituted indole compounds | SUZHOU HEJIAN MEDICAL TECHNOLOGY CO LTD | 2012-10-10 | — | — | CN | disclosed |
| US-20120238018-A1 | Caged Ceramide-1-Phosphate Derivatives | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2012-09-20 | — | — | US | disclosed |
| WO-2011056599-A2 | CAGED CERAMIDE-1-PHOSPHATE DERIVATIVES | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2011-05-12 | — | — | WO | disclosed |
| WO-2011056599-A2 | CAGED CERAMIDE-1-PHOSPHATE DERIVATIVES | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238018-A1 | Caged Ceramide-1-Phosphate Derivatives | CERT1, SGMS1, CERS2 | ALDH1A1 3676/4885TDP1 2653/4885MAPT 2333/4885 |
| US-12234244-B2 | Substituted piperazines as inhibitors of KRAS G12C | KRAS, NRAS, HRAS | ALDH1A1 3870/4885TDP1 3784/4885MAPT 229/4885 |
| US-20240352028-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | ALDH1A1 4009/4885TDP1 2228/4885MAPT 761/4885 |
| US-20140323730-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | ACACA, ACACB, ACAT1 | ALDH1A1 105/4885TDP1 4275/4885MAPT 1315/4885 |
| US-20120270893-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | ACACA, ACACB, ACAT1 | ALDH1A1 105/4885TDP1 4275/4885MAPT 1315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.