Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GRN | P28799 | 1/20 | 0.51 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1903600 | 0.91 | KDM4E (0.60) | LMNABRAFMAPK14NPSR1KDM4E | |
| SCHEMBL5906560 | 0.87 | BRAF (0.54) | LMNABRAFKDRMAPK14KCNK9 | |
| SCHEMBL1905801 | 0.83 | NPSR1 (0.77) | LMNANPSR1KDM4EGRNSORT1 | |
| SCHEMBL1900620 | 0.80 | MAPK14 (0.59) | LMNABRAFMAPK14NPSR1KDM4E | |
| SCHEMBL1903709 | 0.79 | MAPT (0.68) | LMNABRAFMAPK14NPSR1KDM4E | |
| SCHEMBL5906578 | 0.77 | NPSR1 (0.55) | NPSR1GRNSORT1KMT2AMEN1 | |
| SCHEMBL4425426 | 0.77 | NPSR1 (0.59) | MAPK14NPSR1KDM4EGRNSORT1 | |
| SCHEMBL1897017 | 0.77 | BRAF (0.58) | BRAFMAPK14NPSR1KDM4EGRN | |
| SCHEMBL6059993 | 0.77 | POLB (0.58) | LMNAMAPK14NPSR1KDM4EGRN | |
| SCHEMBL14107960 | 0.77 | MAPK14 (0.54) | LMNABRAFKDRMAPK14NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |