Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GRN | P28799 | 1/20 | 0.51 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1903709 | 0.87 | MAPT (0.68) | BRAFCNR1CNR2MAPTMEN1 | |
| SCHEMBL1900620 | 0.83 | MAPK14 (0.59) | BRAFCNR1CNR2MAPTMEN1 | |
| SCHEMBL1903600 | 0.81 | KDM4E (0.60) | BRAFCNR1CNR2MAPTMEN1 | |
| SCHEMBL1897821 | 0.80 | NPSR1 (0.78) | CNR1CNR2MAPTMEN1KMT2A | |
| SCHEMBL4257557 | 0.80 | AAK1 (0.55) | BRAFCNR1CNR2MAPTMAPK14 | |
| SCHEMBL6059993 | 0.80 | POLB (0.58) | CNR1CNR2MAPTMEN1KMT2A | |
| SCHEMBL4425426 | 0.80 | NPSR1 (0.59) | CNR1CNR2MAPTMEN1KMT2A | |
| SCHEMBL4257553 | 0.78 | INSR (0.49) | BRAFCNR1CNR2MAPTSMN1; SMN2 | |
| SCHEMBL17936110 | 0.77 | BRAF (0.47) | BRAFCNR1CNR2MAPTSMN1; SMN2 | |
| SCHEMBL1898147 | 0.77 | LMNA (0.55) | BRAFMEN1KMT2AMAPK14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |