Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GRN | P28799 | 1/20 | 0.55 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6059993 | 0.91 | POLB (0.58) | MAPK14KDM4EGRNSORT1MAPT | |
| SCHEMBL1903709 | 0.88 | MAPT (0.68) | MAPK14KDM4EGRNSORT1MAPT | |
| SCHEMBL1903600 | 0.87 | KDM4E (0.60) | MAPK14KDM4EGRNSORT1MAPT | |
| SCHEMBL4425426 | 0.85 | NPSR1 (0.59) | MAPK14KDM4EGRNSORT1MAPT | |
| SCHEMBL1897017 | 0.83 | BRAF (0.58) | MAPK14KDM4EGRNSORT1MAPT | |
| SCHEMBL4257557 | 0.81 | AAK1 (0.55) | MAPK14KDM4EGRNSORT1MAPT | |
| SCHEMBL1898147 | 0.80 | LMNA (0.55) | MAPK14KDM4EGRNSORT1NPSR1 | |
| SCHEMBL4257553 | 0.79 | INSR (0.49) | KDM4EGRNSORT1MAPTNPSR1 | |
| SCHEMBL13234678 | 0.79 | FLT3 (0.62) | MAPK14MEN1KMT2AMAPK13MAPK12 | |
| SCHEMBL17936110 | 0.78 | BRAF (0.47) | KDM4EGRNSORT1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |