SCHEMBL1898463

SCHEMBL1898463

CCCCC(CC)CNc1ccc(O)c2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.46
KMT2A Q03164 5/20 0.46
MAPT P10636 2/20 0.46
MAOA P21397 1/20 0.46
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
TDP1 Q9NUW8 3/20 0.44
LMNA P02545 3/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
MAPK1 P28482 2/20 0.44
NPSR1 Q6W5P4 1/20 0.44
CYP19A1 P11511 1/20 0.43
MTOR P42345 2/20 0.42
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
SIRT2 Q8IXJ6 1/20 0.42
BLM P54132 3/20 0.42
POLB P06746 2/20 0.42
NSD2 O96028 2/20 0.42
RXFP1 Q9HBX9 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1476827 0.92 CYP19A1 (0.50) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL29425649 0.92 ALDH1A1 (0.45) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL2339098 0.92 ALDH1A1 (0.45) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL14843485 0.85 MEN1 (0.42) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL19135947 0.85 MEN1 (0.45) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL4654063 0.84 MAPT (0.50) MEN1KMT2AMAPTMAOARAB9A
SCHEMBL15603977 0.83 MAPT (0.45) MEN1KMT2AMAPTMAOARAB9A
SCHEMBL8431029 0.82 CYP19A1 (0.60) MEN1KMT2AMAPTMAOANPC1
SCHEMBL6530445 0.81 CYP19A1 (0.58) MEN1KMT2AMAPTMAOANPC1
SCHEMBL12267948 0.81 PGAM1 (0.41) MEN1KMT2AMAPTMAOANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2826564-B1 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M INNOVATIVE PROPERTIES CO (US) 2018-12-26 EP disclosed
US-9880102-B2 Microwell array articles and methods of use 3M INNOVATIVE PROPERTIES COMPANY (US) 2018-01-30 US disclosed
US-20170363545-A1 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M INNOVATIVE PROPERTIES CO (US) 2017-12-21 US disclosed
US-9759663-B2 Microwell array articles and methods of use 3M INNOVATIVE PROPERTIES COMPANY (US) 2017-09-12 US disclosed
US-20160025637-A1 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M INNOVATIVE PROPERTIES COMPANY 2016-01-28 US disclosed
EP-2826564-A1 Microwell array articles and methods of use 3M Innovative Properties Company of 3M Center (US) 2015-01-21 EP disclosed
US-20130004967-A1 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M INNOVATIVE PROPERTIES COMPANY 2013-01-03 US disclosed
EP-2504103-A2 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M Innovative Properties Company (US) 2012-10-03 EP disclosed
WO-2011063332-A2 MICROWELL ARRAY ARTICLES AND METHODS OF USE 3M INNOVATIVE PROPERTIES COMPANY (US) 2011-05-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130004967-A1 MICROWELL ARRAY ARTICLES AND METHODS OF USE CD68, ANXA2, ANXA5 MEN1 3326/4885KMT2A 4489/4885MAPT 1788/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.