SCHEMBL18985158

SCHEMBL18985158

Cc1cc(OC(=O)c2ccc(O[Si](C(C)C)(C(C)C)C(C)C)cc2)ccc1O

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 2/20 0.47
KMT2A Q03164 6/20 0.41
LMNA P02545 1/20 0.41
MAPT P10636 4/20 0.39
GAA P10253 1/20 0.39
HPGD P15428 1/20 0.39
ALDH1A1 P00352 2/20 0.38
GBA1 P04062 1/20 0.38
HSD17B10 Q99714 1/20 0.37
TDP1 Q9NUW8 2/20 0.37
PLA2G1B P04054 1/20 0.37
ATG4B Q9Y4P1 1/20 0.37
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA7 P43166 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
MEN1 O00255 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29783272 1.00 NR1H4 (0.47) NR1H4KMT2ALMNAMAPTGAA
SCHEMBL19027542 0.83 KMT2A (0.51) NR1H4KMT2ALMNAMAPTALDH1A1
SCHEMBL23036593 0.82 TDP1 (0.42) KMT2AMAPTHPGDALDH1A1HSD17B10
SCHEMBL23036104 0.81 NR1H4 (0.40) NR1H4KMT2ALMNAMAPTGAA
SCHEMBL767555 0.81 NR1H4 (0.55) NR1H4KMT2ALMNAMAPTGBA1
SCHEMBL19621079 0.81 KMT2A (0.58) NR1H4KMT2ALMNAGAAHPGD
SCHEMBL18985165 0.81 LMNA (0.46) NR1H4KMT2ALMNAMAPTGAA
SCHEMBL767373 0.81 NR1H4 (0.54) NR1H4KMT2ALMNAMAPTALDH1A1
SCHEMBL19630948 0.80 NR1H4 (0.54) NR1H4KMT2ALMNAMAPTALDH1A1
SCHEMBL14339402 0.79 NR1H4 (0.72) NR1H4KMT2ALMNAMAPTGBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3784751-B1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2024-08-07 EP disclosed
US-11312907-B2 Liquid crystal mixture and liquid crystal display MERCK PATENT GMBH (DE) 2022-04-26 US disclosed
US-11312907-B2 Liquid crystal mixture and liquid crystal display MERCK PATENT GMBH (DE) 2022-04-26 US disclosed
US-20220106525-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2022-04-07 US disclosed
EP-3864111-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY Merck Patent GmbH (DE) 2021-08-18 EP disclosed
US-11053442-B2 Liquid crystal mixture and liquid crystal display MERCK PATENT GMBH (DE) 2021-07-06 US disclosed
US-11053442-B2 Liquid crystal mixture and liquid crystal display MERCK PATENT GMBH (DE) 2021-07-06 US disclosed
US-20210071081-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2021-03-11 US disclosed
US-20210071081-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2021-03-11 US disclosed
EP-3784751-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY Merck Patent GmbH (DE) 2021-03-03 EP disclosed
US-20200255740-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2020-08-13 US disclosed
US-20200255740-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2020-08-13 US disclosed
EP-3390570-B1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2020-03-18 EP disclosed
EP-3390570-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY Merck Patent GmbH (DE) 2018-10-24 EP disclosed
WO-2017102068-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2017-06-22 WO disclosed
WO-2017102068-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2017-06-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220106525-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY CXCR1, PYM1, F11 NR1H4 1969/4885KMT2A 4249/4885LMNA 1207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.