Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MPI | P34949 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18985260 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1HSD17B1HSD17B2 | |
| SCHEMBL19003470 | 0.89 | RAB9A (0.65) | SMN1; SMN2RAB9ANPC1HSD17B1HSD17B2 | |
| SCHEMBL18985199 | 0.89 | NAMPT (0.48) | SMN1; SMN2RAB9ANPC1HSD17B1HSD17B2 | |
| SCHEMBL19003232 | 0.84 | RAB9A (0.53) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL19003252 | 0.84 | RAB9A (0.53) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL19003359 | 0.84 | HDAC3 (0.54) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL18985289 | 0.81 | MAOB (0.64) | SMN1; SMN2RAB9ANPC1HSD17B1HSD17B2 | |
| SCHEMBL18985528 | 0.79 | NQO2 (0.56) | SMN1; SMN2RAB9ANPC1HSD17B1HSD17B2 | |
| SCHEMBL19003466 | 0.79 | NQO2 (0.56) | SMN1; SMN2RAB9ANPC1HSD17B1HSD17B2 | |
| SCHEMBL19003314 | 0.79 | MAOB (0.53) | SMN1; SMN2RAB9ANPC1HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | disclosed |