SCHEMBL18985272

SCHEMBL18985272

O=C(/C=C/c1ccc(Br)s1)Nc1cccc(Br)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.63
MAOA P21397 5/20 0.63
TGM2 P21980 1/20 0.55
EGFR P00533 2/20 0.54
TRPV1 Q8NER1 1/20 0.53
RAB9A P51151 3/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
MEN1 O00255 2/20 0.51
MAPT P10636 2/20 0.51
KMT2A Q03164 2/20 0.51
LMNA P02545 1/20 0.51
TP53 P04637 1/20 0.51
NPC1 O15118 2/20 0.50
MITF O75030 1/20 0.50
HTT P42858 1/20 0.50
MMP1 P03956 3/20 0.45
MMP2 P08253 3/20 0.45
MMP9 P14780 3/20 0.45
GAA P10253 1/20 0.44
LPAR1 Q92633 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19003251 0.87 EGFR (0.68) MAOBMAOAEGFRTRPV1RAB9A
SCHEMBL19003258 0.83 TRPV1 (0.61) TRPV1RAB9ASMN1; SMN2MEN1MAPT
SCHEMBL19003252 0.83 RAB9A (0.53) MAOBMAOAEGFRRAB9ASMN1; SMN2
SCHEMBL19003464 0.80 EGFR (0.53) EGFRRAB9ASMN1; SMN2MEN1MAPT
SCHEMBL19003250 0.78 MAPT (0.51) EGFRRAB9ASMN1; SMN2MEN1MAPT
SCHEMBL19003355 0.78 MAPT (0.48) MAOBMAOAEGFRRAB9ASMN1; SMN2
SCHEMBL704743 0.77 MAOB (1.00) MAOBMAOAEGFRTRPV1RAB9A
SCHEMBL704742 0.77 MAOB (1.00) MAOBMAOAEGFRTRPV1RAB9A
SCHEMBL30894566 0.77 MAOB (1.00) MAOBMAOAEGFRTRPV1RAB9A
SCHEMBL19003247 0.77 MAPT (0.60) EGFRRAB9ASMN1; SMN2MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017102014-A1 PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE UNIVERSITE D'AIX-MARSEILLE (FR) 2017-06-22 WO claimed
WO-2017102014-A1 PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE UNIVERSITE D'AIX-MARSEILLE (FR) 2017-06-22 WO disclosed
WO-2017102014-A1 PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE UNIVERSITE D'AIX-MARSEILLE (FR) 2017-06-22 WO disclosed