SCHEMBL18985303

SCHEMBL18985303

CCCOc1ccc(CNC(=O)/C=C/c2cnc(-c3ccccc3)s2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 8/20 0.53
HDAC3 O15379 7/20 0.53
HDAC4 P56524 7/20 0.53
HDAC1 Q13547 7/20 0.53
HDAC7 Q8WUI4 7/20 0.53
HDAC2 Q92769 7/20 0.53
HDAC10 Q969S8 7/20 0.53
HDAC11 Q96DB2 7/20 0.53
HDAC6 Q9UBN7 7/20 0.53
HDAC9 Q9UKV0 7/20 0.53
HDAC5 Q9UQL6 7/20 0.53
POLB P06746 3/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
PPARA Q07869 1/20 0.47
CYP3A4 P08684 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
MEN1 O00255 1/20 0.43
RECQL P46063 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18985266 0.87 HDAC8 (0.56) HDAC8HDAC3HDAC4HDAC1HDAC7
SCHEMBL18985292 0.83 HDAC8 (0.54) HDAC8HDAC3HDAC4HDAC1HDAC7
SCHEMBL19003361 0.75 NAMPT (0.52) HDAC8HDAC3HDAC4HDAC1HDAC7
SCHEMBL19003360 0.72 HDAC1 (0.46) HDAC8HDAC3HDAC4HDAC1HDAC7
SCHEMBL19003461 0.70 EGFR (0.54) HDAC8NPC1RAB9AMEN1KMT2A
SCHEMBL24702461 0.69 HDAC3 (0.45) HDAC8HDAC3HDAC4HDAC1HDAC7
SCHEMBL20766426 0.68 FAAH (0.70) POLBNPC1RAB9ARECQLLMNA
SCHEMBL18985229 0.68 ACACB (0.50) POLBNPC1RAB9ACYP3A4SMN1; SMN2
SCHEMBL19003308 0.68 EGFR (0.54) HDAC8NPC1RAB9ASMN1; SMN2MEN1
SCHEMBL16055827 0.68 CYP3A4 (0.55) HDAC8HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017102014-A1 PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE UNIVERSITE D'AIX-MARSEILLE (FR) 2017-06-22 WO claimed
WO-2017102014-A1 PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE UNIVERSITE D'AIX-MARSEILLE (FR) 2017-06-22 WO disclosed
WO-2017102014-A1 PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE UNIVERSITE D'AIX-MARSEILLE (FR) 2017-06-22 WO disclosed