Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.47 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18985292 | 0.88 | HDAC8 (0.54) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18985303 | 0.87 | HDAC8 (0.53) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19003361 | 0.85 | NAMPT (0.52) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19003461 | 0.83 | EGFR (0.54) | HDAC8EGFRMEN1KMT2ANPC1 | |
| SCHEMBL19003308 | 0.81 | EGFR (0.54) | HDAC8EGFRMEN1KMT2ANPC1 | |
| SCHEMBL19003360 | 0.77 | HDAC1 (0.46) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18985197 | 0.76 | MEN1 (0.55) | EGFRMEN1KMT2ANPC1LMNA | |
| SCHEMBL19003312 | 0.75 | MEN1 (0.47) | HDAC8EGFRMEN1KMT2ANPC1 | |
| SCHEMBL19003359 | 0.74 | HDAC3 (0.54) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19003273 | 0.74 | MEN1 (0.55) | EGFRMEN1KMT2ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | claimed |
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | disclosed |