Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | PNLIP | P16233 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18985281 | 0.88 | NAMPT (0.49) | NAMPTPNLIPHDAC3ABL1EGFR | |
| SCHEMBL19003361 | 0.78 | NAMPT (0.52) | NAMPTPNLIPHDAC3HDAC4HDAC1 | |
| SCHEMBL18985314 | 0.76 | MAPT (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL19003279 | 0.74 | ALDH1A1 (0.47) | NAMPTHDAC3EGFRHDAC4HDAC1 | |
| SCHEMBL19003461 | 0.72 | EGFR (0.54) | NAMPTEGFRHDAC8ALDH1A1MAPT | |
| SCHEMBL19003312 | 0.72 | MEN1 (0.47) | NAMPTEGFRHDAC8ALDH1A1MAPT | |
| SCHEMBL19003456 | 0.70 | MAPT (0.48) | EGFRALDH1A1HTTMAPTTP53 | |
| SCHEMBL11812683 | 0.68 | MAPT (0.76) | PNLIPEGFRERBB2ALDH1A1HTT | |
| SCHEMBL4007931 | 0.67 | BCHE (0.55) | NAMPTEGFRBCHEACHE | |
| SCHEMBL5108944 | 0.67 | BCHE (0.55) | NAMPTEGFRBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | claimed |