Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27969858 | 0.83 | MEN1 (0.40) | THRBTDP1MAPTBLM | |
| SCHEMBL1325109 | 0.78 | THRB (0.38) | THRBTDP1AKR1C1GAAMAPT | |
| SCHEMBL2144060 | 0.75 | THRB (0.36) | THRBTDP1AKR1C1GAAMAPT | |
| SCHEMBL3696570 | 0.75 | ALDH1A1 (0.44) | THRBTDP1MAPTLMNABLM | |
| SCHEMBL18986791 | 0.71 | AKR1C1 (0.33) | THRBTDP1AKR1C1GAAMAPT | |
| SCHEMBL6829064 | 0.70 | CYP3A4 (0.40) | THRBTDP1MAPTLMNA | |
| SCHEMBL28027267 | 0.69 | ALDH1A1 (0.41) | MAPT | |
| SCHEMBL27923863 | 0.69 | NPC1 (0.32) | — | |
| SCHEMBL5179163 | 0.69 | CHRM2 (0.38) | — | |
| SCHEMBL6829176 | 0.68 | KDM4E (0.35) | THRBTDP1GAAMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390396-A1 | ISOINDOLE COMPOUNDS | Astrazeneca AB (SE) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017102784-A9 | ISOINDOLE COMPOUNDS | ASTRAZENECA AB (SE) | 2018-04-05 | — | — | WO | disclosed |
| WO-2017102784-A1 | ISOINDOLE COMPOUNDS | ASTRAZENECA AB (SE) | 2017-06-22 | — | — | WO | disclosed |