SCHEMBL18987136

SCHEMBL18987136

CC(C)[C@H]1CCC(=O)N1C(=O)OC(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.41
CHRM1 P11229 1/20 0.41
CHRM3 P20309 1/20 0.41
MAPT P10636 2/20 0.36
ELANE P08246 1/20 0.36
NPC1 O15118 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPK1 P28482 1/20 0.36
HTT P42858 1/20 0.36
RAB9A P51151 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
KLK7 P49862 1/20 0.36
KLK5 Q9Y337 1/20 0.36
ACE P12821 2/20 0.35
KDM4E B2RXH2 1/20 0.35
THRB P10828 1/20 0.35
DDB1 Q16531 2/20 0.35
CRBN Q96SW2 2/20 0.35
NR1H2 P55055 2/20 0.35
NR1H3 Q13133 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29624640 1.00 CHRM2 (0.41) CHRM2CHRM1CHRM3MAPTELANE
SCHEMBL4035983 1.00 CHRM2 (0.41) CHRM2CHRM1CHRM3MAPTELANE
SCHEMBL4035987 1.00 CHRM2 (0.41) CHRM2CHRM1CHRM3MAPTELANE
SCHEMBL29261319 0.88 CHRM2 (0.39) CHRM2CHRM1CHRM3MAPTELANE
SCHEMBL29261316 0.88 CHRM2 (0.39) CHRM2CHRM1CHRM3MAPTELANE
SCHEMBL29261317 0.88 CHRM2 (0.39) CHRM2CHRM1CHRM3MAPTELANE
SCHEMBL3378115 0.85 CHRM2 (0.40) CHRM2CHRM1CHRM3MAPTNPC1
SCHEMBL14141084 0.85 CHRM2 (0.40) CHRM2CHRM1CHRM3MAPTNPC1
SCHEMBL27378721 0.84 CHRM2 (0.38) CHRM2CHRM1CHRM3MAPTELANE
SCHEMBL31080746 0.80 CHRM2 (0.36) CHRM2CHRM1CHRM3MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122055156-A (R) -N-ethyl-5-fluoro-N-isopropyl-2- ((5- (2- (6- ((2-methoxyethyl) (methyl) amino) -2-methyl-hex-3-yl) -2, 6-diazaspiro [3.4] oct-6-yl) -1,2, 4-triazin-6-yl) oxy) benzamide, formulations and dosing regimens for treating cancer 詹森药业有限公司 2026-05-15 CN disclosed
US-20260125387-A1 (R)-N-ETHYL-5-FLUORO-N-ISOPROPYL-2-((5-(2-(6-((2-METHOXYETHYL)(METHYL)AMINO)-2-METHYLHEXAN-3-YL)-2,6-DIAZASPIRO[3.4]OCTAN-6-YL)-1,2,4-TRIAZIN-6-YL)OXY)BENZAMIDE BESYLATE SALT JANSSEN PHARMACEUTICA NV (BE) 2026-05-07 US disclosed
EP-4698182-A1 COMBINATION OF A MENIN-LL1 INHIBITOR, A DNA INTERCALATING AGENT AND A PYRIMIDINE ANALOGUE TO TREAT A HEMATOPOIETIC DISORDER Janssen Pharmaceutica NV (BE) 2026-02-25 EP disclosed
US-12473295-B2 Substituted straight chain spiro derivatives JANSSEN PHARMACEUTICA NV (BE) 2025-11-18 US disclosed
US-20250302840-A1 COMBINATION THERAPIES JANSSEN-CILAG (FR) 2025-10-02 US disclosed
WO-2025082444-A2 (R) -N-ETHYL-5-FLUORO-N-ISOPROPYL-2- ( (5- (2- (6- ( (2-METHOXYETHYL) (METHYL) AMINO) -2-METHYLHEXAN-3-YL) -2, 6-DIAZASPIRO [3.4] OCTAN-6-YL) -1, 2, 4-TRIAZIN-6-YL) OXY) BENZAMIDE, FORMULATIONS AND DOSAGE REGIMENS THEREOF, FOR USE IN TREATING CANCER JANSSEN PHARMACEUTICA NV (BE) 2025-04-24 WO disclosed
CN-118845786-A Combination therapy 詹森药业有限公司 2024-10-29 CN disclosed
CN-118845787-A Combination therapy 詹森药业有限公司 2024-10-29 CN disclosed
CN-118852178-A Compounds for the treatment of diseases such as cancer 詹森药业有限公司 2024-10-29 CN disclosed
WO-2024218072-A1 COMBINATION OF A MENIN-LL1 INHIBITOR, A DNA INTERCALATING AGENT AND A PYRIMIDINE ANALOGUE TO TREAT A HEMATOPOIETIC DISORDER. JANSSEN PHARMACEUTICA NV (BE) 2024-10-24 WO disclosed
WO-2022237719-A1 COMBINATION THERAPIES JANSSEN PHARMACEUTICA NV (BE) 2022-11-17 WO disclosed
WO-2022237719-A1 COMBINATION THERAPIES JANSSEN PHARMACEUTICA NV (BE) 2022-11-17 WO disclosed
EP-4077312-A1 SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES Janssen Pharmaceutica NV (BE) 2022-10-26 EP disclosed
CN-114867721-A Substituted straight-chain spiro derivatives 詹森药业有限公司 2022-08-05 CN disclosed
WO-2021121327-A1 SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2021-06-24 WO disclosed
US-10717754-B2 Metal complexes UNIVERSITY OF LEEDS (GB) 2020-07-21 US disclosed
EP-3390421-B1 METAL COMPLEXES UNIV LEEDS INNOVATIONS LTD (GB) 2020-01-29 EP disclosed
US-20180362566-A1 METAL COMPLEXES UNIVERSITY OF LEEDS (GB) 2018-12-20 US disclosed
EP-3390421-A1 METAL COMPLEXES University of Leeds (GB) 2018-10-24 EP disclosed
WO-2017103623-A1 METAL COMPLEXES UNIVERSITY OF LEEDS (GB) 2017-06-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250302840-A1 COMBINATION THERAPIES MEN1, MLLT1, BMI1 CHRM2 1335/4885CHRM1 1622/4885CHRM3 3205/4885
US-12473295-B2 Substituted straight chain spiro derivatives MLLT1, MEN1, MLLT3 CHRM2 4836/4885CHRM1 4829/4885CHRM3 4796/4885
US-10717754-B2 Metal complexes SDHB, MPI, AP1M1 CHRM2 4775/4885CHRM1 4703/4885CHRM3 4702/4885
US-20180362566-A1 METAL COMPLEXES SDHB, AP1M1, GFPT1 CHRM2 4790/4885CHRM1 4696/4885CHRM3 4693/4885
US-20260125387-A1 (R)-N-ETHYL-5-FLUORO-N-ISOPROPYL-2-((5-(2-(6-((2-METHOXYETHYL)(METHYL)AMINO)-2-METHYLHEXAN-3-YL)-2,6-DIAZASPIRO[3.4]OCTAN-6-YL)-1,2,4-TRIAZIN-6-YL)OXY)BENZAMIDE BESYLATE SALT MLLT1, MEN1, MLLT3 CHRM2 4166/4885CHRM1 4293/4885CHRM3 4037/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.