Sugi Predict

Sugi Predict / Compounds / SCHEMBL18988787

SCHEMBL18988787

SCHEMBL18988787

NN(C(=O)c1ccccc1)C(c1ccccc1)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 6/20 0.41
▸ CES1 P23141 2/20 0.40
▸ NR1H2 P55055 1/20 0.40
▸ NR1H3 Q13133 1/20 0.40
▸ MLYCD O95822 1/20 0.40
▸ PTPN1 P18031 1/20 0.40
▸ LMNA P02545 3/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ TDP1 Q9NUW8 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ CTRB1 P17538 1/20 0.38
▸ POLB P06746 1/20 0.38
▸ NR1I2 O75469 1/20 0.38
▸ CES2 O00748 1/20 0.38
▸ RORC P51449 1/20 0.38
▸ TACR1 P25103 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18988683 0.78 MLYCD (0.48) TRPM8CES1NR1H2NR1H3MLYCD
SCHEMBL18988959 0.75 MLYCD (0.42) TRPM8CES1NR1H2NR1H3MLYCD
SCHEMBL28658327 0.75 MLYCD (0.46) TRPM8CES1NR1H2NR1H3MLYCD
SCHEMBL23150369 0.75 TRPM8 (0.43) TRPM8CES1NR1H2NR1H3MLYCD
SCHEMBL31388076 0.74 ADRA2C (0.43) TRPM8CES1MLYCDALDH1A1TDP1
SCHEMBL22987237 0.74 TRPM8 (0.42) TRPM8LMNATDP1CTRB1POLB
SCHEMBL10904843 0.74 TRPM8 (0.59) TRPM8LMNAALDH1A1TDP1L3MBTL1
SCHEMBL28182286 0.74 TRPM8 (0.59) TRPM8LMNAALDH1A1TDP1L3MBTL1
SCHEMBL28964406 0.73 MLYCD (0.50) TRPM8CES1NR1H2NR1H3MLYCD
SCHEMBL18989293 0.73 MLYCD (0.38) TRPM8CES1NR1H2NR1H3MLYCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250090500-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2025-03-20 — — US disclosed
US-12220401-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY, INC. (US) 2025-02-11 — — US disclosed
US-11826351-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY INC. (US) 2023-11-28 — — US disclosed
US-20230372298-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2023-11-23 — — US disclosed
US-11471441-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY INC. (US) 2022-10-18 — — US disclosed
CN-114716381-A Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2022-07-08 — — CN disclosed
CN-114634447-A Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2022-06-17 — — CN disclosed
CN-114621146-A Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2022-06-14 — — CN disclosed
CN-114605327-A Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2022-06-10 — — CN disclosed
CN-114591242-A Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2022-06-07 — — CN disclosed
CN-108473481-B Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2022-04-19 — — CN disclosed
CN-113636978-A Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2021-11-12 — — CN disclosed
CN-113603645-A Compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2021-11-05 — — CN disclosed
US-20210093611-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2021-04-01 — — US disclosed
US-10918622-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY, INC. (US) 2021-02-16 — — US disclosed
US-20200276162-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2020-09-03 — — US disclosed
US-10464905-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY INC. (US) 2019-11-05 — — US disclosed
US-20190000806-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2019-01-03 — — US disclosed
EP-3390395-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS Loxo Oncology Inc. (US) 2018-10-24 — — EP disclosed
WO-2017103611-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS REDX PHARMA PLC (GB) 2017-06-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12220401-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK TRPM8 2746/4885CES1 3013/4885NR1H2 4272/4885
US-20250090500-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK TRPM8 2746/4885CES1 3013/4885NR1H2 4272/4885
US-10918622-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK TRPM8 2746/4885CES1 3013/4885NR1H2 4272/4885
US-20200276162-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK TRPM8 2746/4885CES1 3013/4885NR1H2 4272/4885
US-11826351-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK TRPM8 2746/4885CES1 3013/4885NR1H2 4272/4885
US-11471441-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK TRPM8 2746/4885CES1 3013/4885NR1H2 4272/4885
US-20230372298-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK TRPM8 2746/4885CES1 3013/4885NR1H2 4272/4885
US-20210093611-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK TRPM8 2746/4885CES1 3013/4885NR1H2 4272/4885
US-10464905-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK TRPM8 2746/4885CES1 3013/4885NR1H2 4272/4885
US-20190000806-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK TRPM8 2746/4885CES1 3013/4885NR1H2 4272/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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